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Dual function of CTLA-4 in regulatory T cells and conventional T cells to prevent multiorgan autoimmunity
Cytotoxic T lymphocyte antigen-4 (CTLA-4) is an inhibitory receptor on T cells essential for maintaining T cell homeostasis and tolerance to self. Mice lacking CTLA-4 develop an early onset, fatal breakdown in T cell tolerance. Whether this autoimmune disease occurs because of the loss of CTLA-4 fun...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2824392/ https://ncbi.nlm.nih.gov/pubmed/20080649 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0910341107 |
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