Cooperative Roles of CTLA-4 and Regulatory T Cells in Tolerance to an Islet Cell Antigen

Adoptive transfer of ovalbumin (OVA)-specific T cells from the DO.11 TCR transgenic mouse on a Rag(−/−) background into mice expressing OVA in pancreatic islet cells induces acute insulitis and diabetes only if endogenous lymphocytes, including regulatory T cells, are removed. When wild-type OVA-spe...

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Detalles Bibliográficos
Main Authors: Eggena, Mark P., Walker, Lucy S.K., Nagabhushanam, Vijaya, Barron, Luke, Chodos, Anna, Abbas, Abul K.
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2004
Assuntos:
Brief Definitive Report
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2212810/
https://ncbi.nlm.nih.gov/pubmed/15210748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20040124
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