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Intrakinetochore stretch is associated with changes in kinetochore phosphorylation and spindle assembly checkpoint activity

Cells have evolved a signaling pathway called the spindle assembly checkpoint (SAC) to increase the fidelity of chromosome segregation by generating a “wait anaphase” signal until all chromosomes are properly aligned within the mitotic spindle. It has been proposed that tension generated by the stre...

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Detalhes bibliográficos
Main Authors: Maresca, Thomas J., Salmon, Edward D.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2646557/
https://ncbi.nlm.nih.gov/pubmed/19193623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200808130
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