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Role of the Phosphatidylinositol-3-Kinase and Extracellular Regulated Kinase Pathways in the Induction of Hypoxia-Inducible Factor (HIF)-1 Activity and the HIF-1 Target Vascular Endothelial Growth Factor in Ovarian Granulosa Cells in Response to Follicle-Stimulating Hormone

FSH stimulation of granulosa cells (GCs) results in increased hypoxia-inducible factor (HIF)-1α protein levels and HIF-1 activity that is necessary for up-regulation of certain FSH target genes including vascular endothelial growth factor. We report that the role of the phosphatidylinositol (PI)-3-k...

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Bibliografiske detaljer
Main Authors: Alam, Hena, Weck, Jennifer, Maizels, Evelyn, Park, Youngkyu, Lee, Eun Jig, Ashcroft, Margaret, Hunzicker-Dunn, Mary
Format: Artigo
Sprog:Inglês
Udgivet: The Endocrine Society 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2646536/
https://ncbi.nlm.nih.gov/pubmed/18845636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2008-0850
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