Follicle-stimulating Hormone Activation of Hypoxia-inducible Factor-1 by the Phosphatidylinositol 3-Kinase/AKT/Ras Homolog Enriched in Brain (Rheb)/Mammalian Target of Rapamycin (mTOR) Pathway Is Necessary for Induction of Select Protein Markers of Follicular Differentiation

We sought to elucidate the role of AKT in follicle-stimulating hormone (FSH)-mediated granulosa cell (GC) differentiation. Our results define a signaling pathway in GCs whereby the inactivating phosphorylation of tuberin downstream of phosphatidylinositol (PI) 3-kinase/AKT activity leads to Rheb (Ra...

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Detalhes bibliográficos
Main Authors: Alam, Hena, Maizels, Evelyn T., Park, Youngkyu, Ghaey, Shail, Feiger, Zachary J., Chandel, Navdeep S., Hunzicker-Dunn, Mary
Formato: Artigo
Idioma:Inglês
Publicado em: 2004
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1564189/
https://ncbi.nlm.nih.gov/pubmed/14982927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M401235200
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