Raf kinase inhibitory protein suppresses a metastasis signalling cascade involving LIN28 and let-7

Raf kinase inhibitory protein (RKIP) negatively regulates the MAP kinase (MAPK), G protein-coupled receptor kinase-2, and NF-κB signalling cascades. RKIP has been implicated as a metastasis suppressor for prostate cancer, but the mechanism is not known. Here, we show that RKIP inhibits invasion by m...

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Bibliographic Details
Main Authors: Dangi-Garimella, Surabhi, Yun, Jieun, Eves, Eva M, Newman, Martin, Erkeland, Stefan J, Hammond, Scott M, Minn, Andy J, Rosner, Marsha Rich
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2646152/
https://ncbi.nlm.nih.gov/pubmed/19153603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.294
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