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Raf Kinase Inhibitory Protein Regulates Aurora B Kinase and the Spindle Checkpoint Via Map Kinase

Raf Kinase Inhibitory Protein (RKIP or PEBP) is an inhibitor of the Raf/MEK/MAP kinase signaling cascade and a suppressor of cancer metastasis. We now show that RKIP associates with centrosomes and kinetochores and regulates the spindle checkpoint in mammalian cells. RKIP depletion causes decreases...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Eves, Eva M., Shapiro, Paul, Naik, Karuna, Klein, Ulf R., Trakul, Nicholas, Rosner, Marsha Rich
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2006
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1626587/
https://ncbi.nlm.nih.gov/pubmed/16916643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2006.07.015
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