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Raf Kinase Inhibitory Protein Regulates Aurora B Kinase and the Spindle Checkpoint Via Map Kinase
Raf Kinase Inhibitory Protein (RKIP or PEBP) is an inhibitor of the Raf/MEK/MAP kinase signaling cascade and a suppressor of cancer metastasis. We now show that RKIP associates with centrosomes and kinetochores and regulates the spindle checkpoint in mammalian cells. RKIP depletion causes decreases...
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| Auteurs principaux: | , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2006
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1626587/ https://ncbi.nlm.nih.gov/pubmed/16916643 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2006.07.015 |
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