Two-polymerase mechanisms dictate error-free and error-prone translesion DNA synthesis in mammals

DNA replication across blocking lesions occurs by translesion DNA synthesis (TLS), involving a multitude of mutagenic DNA polymerases that operate to protect the mammalian genome. Using a quantitative TLS assay, we identified three main classes of TLS in human cells: two rapid and error-free, and th...

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Main Authors: Shachar, Sigal, Ziv, Omer, Avkin, Sharon, Adar, Sheera, Wittschieben, John, Reißner, Thomas, Chaney, Stephen, Friedberg, Errol C, Wang, Zhigang, Carell, Thomas, Geacintov, Nicholas, Livneh, Zvi
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2009
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2646147/
https://ncbi.nlm.nih.gov/pubmed/19153606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.281
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