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Two-polymerase mechanisms dictate error-free and error-prone translesion DNA synthesis in mammals
DNA replication across blocking lesions occurs by translesion DNA synthesis (TLS), involving a multitude of mutagenic DNA polymerases that operate to protect the mammalian genome. Using a quantitative TLS assay, we identified three main classes of TLS in human cells: two rapid and error-free, and th...
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| Main Authors: | , , , , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Nature Publishing Group
2009
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2646147/ https://ncbi.nlm.nih.gov/pubmed/19153606 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.281 |
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