SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

The Sir2 deacetylase regulates chromatin silencing and lifespan in Saccharomyces cerevisiae1,2. In mice, deficiency for the Sir2 family member SIRT6 leads to a shortened lifespan and a premature ageing-like phenotype3. However, the molecular mechanisms of SIRT6 function are unclear. SIRT6 is a chrom...

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Auteurs principaux: Michishita, Eriko, McCord, Ronald A., Berber, Elisabeth, Kioi, Mitomu, Padilla-Nash, Hesed, Damian, Mara, Cheung, Peggie, Kusumoto, Rika, Kawahara, Tiara L. A., Barrett, J. Carl, Chang, Howard Y., Bohr, Vilhelm A., Ried, Thomas, Gozani, Or, Chua, Katrin F.
Format: Artigo
Langue:Inglês
Publié: 2008
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2646112/
https://ncbi.nlm.nih.gov/pubmed/18337721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature06736
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