SIRT6 links histone H3 lysine 9 deacetylation to control of NF-κB dependent gene expression and organismal lifespan

Members of the Sirtuin (SIRT) family of NAD+-dependent deacetylases promote longevity in multiple organisms. Deficiency of mammalian SIRT6 leads to shortened lifespan and an aging-like phenotype in mice, but the underlying molecular mechanisms are unclear. Here we show that SIRT6 functions at chroma...

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Bibliografiset tiedot
Päätekijät: Kawahara, Tiara L.A., Michishita, Eriko, Adler, Adam S., Damian, Mara, Berber, Elisabeth, Lin, Meihong, McCord, Ron A., Ongaigui, Kristine C.L., Boxer, Lisa D., Chang, Howard Y., Chua, Katrin F.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2009
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2757125/
https://ncbi.nlm.nih.gov/pubmed/19135889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2008.10.052
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