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Substitution of aminomethyl at the meta- position enhances the inactivation of O(6)-alkylguanine-DNA alkyltransferase by O(6)-benzylguanine
O(6)-Benzylguanine is an irreversible inactivator of O(6)-alkylguanine-DNA alkyltransferase currently in clinical trials to overcome alkyltransferase-mediated resistance to certain cancer chemotherapeutic alkylating agents. In order to produce more soluble alkyltransferase inhibitors, we have synthe...
Gorde:
| Egile Nagusiak: | , , , , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2008
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2645950/ https://ncbi.nlm.nih.gov/pubmed/18973327 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm800675p |
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