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Monitoring for Lack of Benefit: A Critical Component of a Randomized Clinical Trial

To balance patient interests against the need for acquiring evidence, ongoing randomized clinical trials are formally monitored for early convincing indication of benefit or lack of benefit. In lethal diseases like cancer, where new therapies are often toxic and may have limited preliminary efficacy...

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Hlavní autoři: Freidlin, Boris, Korn, Edward L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Clinical Oncology 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2645857/
https://ncbi.nlm.nih.gov/pubmed/19064977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2008.17.8905
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