Spatial Distribution of Protein Kinase A Activity during Cell Migration Is Mediated by A-kinase Anchoring Protein AKAP Lbc

Protein kinase A (PKA) has been suggested to be spatially regulated in migrating cells due to its ability to control signaling events that are critical for polarized actin cytoskeletal dynamics. Here, using the fluorescence resonance energy transfer-based A-kinase activity reporter (AKAR1), we find...

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Bibliographische Detailangaben
Hauptverfasser: Paulucci-Holthauzen, Adriana A., Vergara, Leoncio A., Bellot, Larry J., Canton, David, Scott, John D., O'Connor, Kathleen L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2009
Schlagworte:
Mechanisms of Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2645839/
https://ncbi.nlm.nih.gov/pubmed/19106088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M805606200
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