Spatial Distribution of Protein Kinase A Activity during Cell Migration Is Mediated by A-kinase Anchoring Protein AKAP Lbc

Protein kinase A (PKA) has been suggested to be spatially regulated in migrating cells due to its ability to control signaling events that are critical for polarized actin cytoskeletal dynamics. Here, using the fluorescence resonance energy transfer-based A-kinase activity reporter (AKAR1), we find...

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Detalhes bibliográficos
Main Authors: Paulucci-Holthauzen, Adriana A., Vergara, Leoncio A., Bellot, Larry J., Canton, David, Scott, John D., O'Connor, Kathleen L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2645839/
https://ncbi.nlm.nih.gov/pubmed/19106088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M805606200
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