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Methylalpinumisoflavone Inhibits Hypoxia-inducible Factor-1 (HIF-1) Activation by Simultaneously Targeting Multiple Pathways

Hypoxia is a common feature of solid tumors, and the extent of tumor hypoxia correlates with advanced disease stages and treatment resistance. The transcription factor hypoxia-inducible factor-1 (HIF-1) represents an important tumor-selective molecular target for anticancer drug discovery directed a...

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Библиографические подробности
Главные авторы: Liu, Yang, Veena, Coothan K., Morgan, J. Brian, Mohammed, Kaleem A., Jekabsons, Mika B., Nagle, Dale G., Zhou, Yu-Dong
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2009
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2645834/
https://ncbi.nlm.nih.gov/pubmed/19091749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806744200
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