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Knockout of spinophilin, an endogenous antagonist of arrestin-dependent α(2)-adrenoceptor functions, enhances receptor-mediated antinociception yet does not eliminate sex-related differences
We have previously shown gonadal steroid-dependent, gender specific modulation of nociception by α(2)-adrenoceptors. Agonist activation of the receptor enhances its association with spinophilin that antagonizes arrestin functions both by diminishing receptor phosphorylation by G-protein-coupled rece...
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| Asıl Yazarlar: | , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2008
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2645350/ https://ncbi.nlm.nih.gov/pubmed/18957308 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbr.2008.09.036 |
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