Phase I Trial of Interleukin-12 Plasmid Electroporation in Patients With Metastatic Melanoma

PURPOSE: Gene-based immunotherapy for cancer is limited by the lack of safe, efficient, reproducible, and titratable delivery methods. Direct injection of DNA into tissue, although safer than viral vectors, suffers from low gene transfer efficiency. In vivo electroporation, in preclinical models, si...

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Bibliografiske detaljer
Main Authors: Daud, Adil I., DeConti, Ronald C., Andrews, Stephanie, Urbas, Patricia, Riker, Adam I., Sondak, Vernon K., Munster, Pamela N., Sullivan, Daniel M., Ugen, Kenneth E., Messina, Jane L., Heller, Richard
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Clinical Oncology 2008
Fag:
Immunotherapy
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2645111/
https://ncbi.nlm.nih.gov/pubmed/19029422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2007.15.6794
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