Phase I Trial of Interleukin-12 Plasmid Electroporation in Patients With Metastatic Melanoma

PURPOSE: Gene-based immunotherapy for cancer is limited by the lack of safe, efficient, reproducible, and titratable delivery methods. Direct injection of DNA into tissue, although safer than viral vectors, suffers from low gene transfer efficiency. In vivo electroporation, in preclinical models, si...

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Autori principali: Daud, Adil I., DeConti, Ronald C., Andrews, Stephanie, Urbas, Patricia, Riker, Adam I., Sondak, Vernon K., Munster, Pamela N., Sullivan, Daniel M., Ugen, Kenneth E., Messina, Jane L., Heller, Richard
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Clinical Oncology 2008
Soggetti:
Immunotherapy
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2645111/
https://ncbi.nlm.nih.gov/pubmed/19029422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2007.15.6794
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