Phase I Trial of Interleukin-12 Plasmid Electroporation in Patients With Metastatic Melanoma

PURPOSE: Gene-based immunotherapy for cancer is limited by the lack of safe, efficient, reproducible, and titratable delivery methods. Direct injection of DNA into tissue, although safer than viral vectors, suffers from low gene transfer efficiency. In vivo electroporation, in preclinical models, si...

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Detalles Bibliográficos
Main Authors: Daud, Adil I., DeConti, Ronald C., Andrews, Stephanie, Urbas, Patricia, Riker, Adam I., Sondak, Vernon K., Munster, Pamela N., Sullivan, Daniel M., Ugen, Kenneth E., Messina, Jane L., Heller, Richard
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Clinical Oncology 2008
Assuntos:
Immunotherapy
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2645111/
https://ncbi.nlm.nih.gov/pubmed/19029422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2007.15.6794
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