Phase II trial of sagopilone, a novel epothilone analog in metastatic melanoma

BACKGROUND: Sagopilone is a novel fully synthetic epothilone with promising preclinical activity and a favourable toxicity profile in phase I testing. METHODS: A phase II pharmacokinetic and efficacy trial was conducted in patients with metastatic melanoma. Patients had measurable disease, Eastern C...

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Autors principals: DeConti, R C, Algazi, A P, Andrews, S, Urbas, P, Born, O, Stoeckigt, D, Floren, L, Hwang, J, Weber, J, Sondak, V K, Daud, A I
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2010
Matèries:
Clinical Study
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2990578/
https://ncbi.nlm.nih.gov/pubmed/20924376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605931
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