Mitochondrial abnormalities in spinal and bulbar muscular atrophy

Spinal and bulbar muscular atrophy (SBMA) is a motor neuron disease caused by polyglutamine expansion mutation in the androgen receptor (AR). We investigated whether the mutant protein alters mitochondrial function. We found that constitutive and doxycycline-induced expression of the mutant AR in MN...

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Bibliografiske detaljer
Main Authors: Ranganathan, Srikanth, Harmison, George G., Meyertholen, Kristin, Pennuto, Maria, Burnett, Barrington G., Fischbeck, Kenneth H.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2009
Fag:
Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2644643/
https://ncbi.nlm.nih.gov/pubmed/18824496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddn310
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