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Structure and Substrate Recruitment of the Human Spindle Checkpoint Kinase Bub1
In mitosis, the spindle checkpoint detects a single unattached kinetochore, inhibits the anaphase-promoting complex or cyclosome (APC/C), and prevents premature sister-chromatid separation. The checkpoint kinase Bub1 contributes to checkpoint sensitivity through phosphorylating the APC/C activator,...
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| Autors principals: | , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2008
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2644263/ https://ncbi.nlm.nih.gov/pubmed/18995837 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2008.09.017 |
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