Structure and Substrate Recruitment of the Human Spindle Checkpoint Kinase Bub1

In mitosis, the spindle checkpoint detects a single unattached kinetochore, inhibits the anaphase-promoting complex or cyclosome (APC/C), and prevents premature sister-chromatid separation. The checkpoint kinase Bub1 contributes to checkpoint sensitivity through phosphorylating the APC/C activator,...

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Main Authors: Kang, Jungseog, Yang, Maojun, Li, Bing, Qi, Wei, Zhang, Chao, Shokat, Kevan M., Tomchick, Diana R., Machius, Mischa, Yu, Hongtao
Format: Artigo
Sprog:Inglês
Udgivet: 2008
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2644263/
https://ncbi.nlm.nih.gov/pubmed/18995837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2008.09.017
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