Enhanced exercise capacity in mice with severe heart failure treated with an allosteric effector of hemoglobin, myo-inositol trispyrophosphate

A major determinant of maximal exercise capacity is the delivery of oxygen to exercising muscles. myo-Inositol trispyrophosphate (ITPP) is a recently identified membrane-permeant molecule that causes allosteric regulation of Hb oxygen binding affinity. In normal mice, i.p. administration of ITPP (0....

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Main Authors: Biolo, Andreia, Greferath, Ruth, Siwik, Deborah A., Qin, Fuzhong, Valsky, Eugene, Fylaktakidou, Konstantina C., Pothukanuri, Srinivasu, Duarte, Carolina D., Schwarz, Richard P., Lehn, Jean-Marie, Nicolau, Claude, Colucci, Wilson S.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2009
Fag:
Physical Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2644140/
https://ncbi.nlm.nih.gov/pubmed/19204295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0812381106
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