Suppression of hypoxia-induced HIF-1α and of angiogenesis in endothelial cells by myo-inositol trispyrophosphate-treated erythrocytes

Allosteric regulation of oxygen delivery by RBCs may have significant effects on tumor growth. Indeed, angiogenesis, the formation of new blood vessels, is induced in growing tumors by low oxygen partial pressure. Hypoxia-inducible genes are switched on, among which are the VEGF gene and its recepto...

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Библиографические подробности
Главные авторы: Kieda, Claudine, Greferath, Ruth, Crola Da Silva, Claire, Fylaktakidou, Konstantina C., Lehn, Jean-Marie, Nicolau, Claude
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2006
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1622864/
https://ncbi.nlm.nih.gov/pubmed/17028170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0607109103
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