Phase Ib dose-escalation study of the hypoxia-modifier Myo-inositol trispyrophosphate in patients with hepatopancreatobiliary tumors

Hypoxia is prominent in solid tumors and a recognized driver of malignancy. Thus far, targeting tumor hypoxia has remained unsuccessful. Myo-inositol trispyrophosphate (ITPP) is a re-oxygenating compound without apparent toxicity. In preclinical models, ITPP potentiates the efficacy of subsequent ch...

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Vydáno v:Nat Commun
Hlavní autoři: Schneider, Marcel A., Linecker, Michael, Fritsch, Ralph, Muehlematter, Urs J., Stocker, Daniel, Pestalozzi, Bernhard, Samaras, Panagiotis, Jetter, Alexander, Kron, Philipp, Petrowsky, Henrik, Nicolau, Claude, Lehn, Jean-Marie, Humar, Bostjan, Graf, Rolf, Clavien, Pierre-Alain, Limani, Perparim
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8217170/
https://ncbi.nlm.nih.gov/pubmed/34155211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24069-w
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