Recurrent genomic alterations characterize medulloblastoma arising from DNA double-strand break repair deficiency

Inactivation of homologous recombination (HR) or nonhomologous end-joining (NHEJ) predisposes to a spectrum of tumor types. Here, we inactivated DNA double-strand break repair (DSBR) proteins, DNA Ligase IV (Lig4), Xrcc2, and Brca2, or combined Lig4/Xrcc2 during neural development using Nestin-cre....

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Autori principali: Frappart, Pierre-Olivier, Lee, Youngsoo, Russell, Helen R., Chalhoub, Nader, Wang, Yong-Dong, Orii, Kenji E., Zhao, Jingfeng, Kondo, Naomi, Baker, Suzanne J., McKinnon, Peter J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2009
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2644132/
https://ncbi.nlm.nih.gov/pubmed/19164512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0806882106
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