Increased expression of urokinase plasminogen activator in Quebec platelet disorder is linked to megakaryocyte differentiation

Quebec platelet disorder (QPD) is an inherited bleeding disorder associated with increased urokinase plasminogen activator (uPA) in platelets but not in plasma, intraplatelet plasmin generation, and α-granule protein degradation. These abnormalities led us to investigate uPA expression by QPD CD34(+...

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Autores principales: Veljkovic, D. Kika, Rivard, Georges E., Diamandis, Maria, Blavignac, Jessica, Cramer-Bordé, Elisabeth M., Hayward, Catherine P. M.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2009
Materias:
Platelets and Thrombopoiesis
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2644081/
https://ncbi.nlm.nih.gov/pubmed/19029443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-08-172338
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