Quebec platelet disorder is linked to the urokinase plasminogen activator gene (PLAU) and increases expression of the linked allele in megakaryocytes

Quebec platelet disorder (QPD) is an autosomal dominant disorder with high penetrance that is associated with increased risks for bleeding. The hallmark of QPD is a gain-of-function defect in fibrinolysis due to increased platelet content of urokinase plasminogen activator (uPA) without systemic fib...

Full description

Saved in:
Bibliographic Details
Main Authors: Diamandis, Maria, Paterson, Andrew D., Rommens, Johanna M., Veljkovic, D. Kika, Blavignac, Jessica, Bulman, Dennis E., Waye, John S., Derome, Francine, Rivard, Georges E., Hayward, Catherine P. M.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2009
Subjects:
Platelets and Thrombopoiesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2644082/
https://ncbi.nlm.nih.gov/pubmed/18988861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-08-175216
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items