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Quebec platelet disorder is linked to the urokinase plasminogen activator gene (PLAU) and increases expression of the linked allele in megakaryocytes

Quebec platelet disorder (QPD) is an autosomal dominant disorder with high penetrance that is associated with increased risks for bleeding. The hallmark of QPD is a gain-of-function defect in fibrinolysis due to increased platelet content of urokinase plasminogen activator (uPA) without systemic fib...

詳細記述

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書誌詳細
主要な著者: Diamandis, Maria, Paterson, Andrew D., Rommens, Johanna M., Veljkovic, D. Kika, Blavignac, Jessica, Bulman, Dennis E., Waye, John S., Derome, Francine, Rivard, Georges E., Hayward, Catherine P. M.
フォーマット: Artigo
言語:Inglês
出版事項: American Society of Hematology 2009
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2644082/
https://ncbi.nlm.nih.gov/pubmed/18988861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-08-175216
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