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Mll5 contributes to hematopoietic stem cell fitness and homeostasis

MLL5 is a novel trithorax group gene and a candidate tumor suppressor gene located within a 2.5-Mb interval of chromosome band 7q22 that frequently is deleted in human myeloid malignancy. Here we show that inactivation of the Mll5 gene in mice results in a 30% reduction in the average representation...

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Autors principals: Zhang, Yan, Wong, Jasmine, Klinger, Mark, Tran, Mary T., Shannon, Kevin M., Killeen, Nigel
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2644073/
https://ncbi.nlm.nih.gov/pubmed/18818388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-05-159905
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