Airway smooth muscle hyperplasia and hypertrophy correlate with glycogen synthase kinase-3β phosphorylation in a mouse model of asthma

Increased airway smooth muscle (ASM) mass, a characteristic finding in asthma, may be caused by hyperplasia or hypertrophy. Cell growth requires increased translation of contractile apparatus mRNA, which is controlled, in part, by glycogen synthase kinase (GSK)-3β, a constitutively active kinase tha...

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Bibliographic Details
Main Authors: Bentley, J. Kelley, Deng, Huan, Linn, Marisa J., Lei, Jing, Dokshin, Gregoriy A., Fingar, Diane C., Bitar, Khalil N., Henderson, William R., Hershenson, Marc B.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2009
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2643992/
https://ncbi.nlm.nih.gov/pubmed/19011050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.90376.2008
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