Inhibition of p66ShcA redox activity in cardiac muscle cells attenuates hyperglycemia-induced oxidative stress and apoptosis

Apoptotic myocyte cell death, diastolic dysfunction, and progressive deterioration in left ventricular pump function characterize the clinical course of diabetic cardiomyopathy. A key question concerns the mechanism(s) by which hyperglycemia (HG) transmits danger signals in cardiac muscle cells. The...

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Bibliographische Detailangaben
Hauptverfasser: Malhotra, Ashwani, Vashistha, Himanshu, Yadav, Virendra S., Dube, Michael G., Kalra, Satya P., Abdellatif, Maha, Meggs, Leonard G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2009
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2643882/
https://ncbi.nlm.nih.gov/pubmed/19060130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00225.2008
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