Inhibition of p66ShcA Longevity Gene Rescues Podocytes from HIV-1-induced Oxidative Stress and Apoptosis

Glomerular visceral epithelial cells (podocytes) play a critical role in the pathogenesis of human immunodeficiency virus (HIV)-associated nephropathy. A key question concerns the mechanism(s) by which the HIV-1 genome alters the phenotype of the highly specialized, terminally differentiated podocyt...

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Main Authors: Husain, Mohammad, Meggs, Leonard G., Vashistha, Himanshu, Simoes, Sonia, Griffiths, Kevin O., Kumar, Dileep, Mikulak, Joanna, Mathieson, Peter W., Saleem, Moin A., Del Valle, Luis, Pina-Oviedo, Sergio, Wang, Jin Ying, Seshan, Surya V., Malhotra, Ashwani, Reiss, Krzysztof, Singhal, Pravin C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2713565/
https://ncbi.nlm.nih.gov/pubmed/19383602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.008482
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