Dense-core vesicle proteins IA-2 and IA-2β affect renin synthesis and secretion through the β-adrenergic pathway

IA-2 and IA-2β, major autoantigens in type 1 diabetes, are transmembrane proteins in dense-core vesicles, and their expression influences the secretion of hormones and neurotransmitters. The present experiments were performed to examine whether IA-2 and IA-2β modulate the release of renin from dense...

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Main Authors: Kim, Soo Mi, Theilig, Franziska, Qin, Yan, Cai, Tao, Mizel, Diane, Faulhaber-Walter, Robert, Hirai, Hiroki, Bachmann, Sebastian, Briggs, Josephine P., Notkins, Abner L., Schnermann, Jurgen
Format: Artigo
Language:Inglês
Published: American Physiological Society 2009
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2643864/
https://ncbi.nlm.nih.gov/pubmed/19019914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.90543.2008
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