Raf Kinase Inhibitory Protein Function Is Regulated via a Flexible Pocket and Novel Phosphorylation-Dependent Mechanism

Raf kinase inhibitory protein (RKIP/PEBP1), a member of the phosphatidylethanolamine binding protein family that possesses a conserved ligand-binding pocket, negatively regulates the mammalian mitogen-activated protein kinase (MAPK) signaling cascade. Mutation of a conserved site (P74L) within the p...

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Main Authors: Granovsky, Alexey E., Clark, Matthew C., McElheny, Dan, Heil, Gary, Hong, Jia, Liu, Xuedong, Kim, Youngchang, Joachimiak, Grazyna, Joachimiak, Andrzej, Koide, Shohei, Rosner, Marsha Rich
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2643833/
https://ncbi.nlm.nih.gov/pubmed/19103740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01271-08
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