Raf Kinase Inhibitory Protein Function Is Regulated via a Flexible Pocket and Novel Phosphorylation-Dependent Mechanism

Raf kinase inhibitory protein (RKIP/PEBP1), a member of the phosphatidylethanolamine binding protein family that possesses a conserved ligand-binding pocket, negatively regulates the mammalian mitogen-activated protein kinase (MAPK) signaling cascade. Mutation of a conserved site (P74L) within the p...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Granovsky, Alexey E., Clark, Matthew C., McElheny, Dan, Heil, Gary, Hong, Jia, Liu, Xuedong, Kim, Youngchang, Joachimiak, Grazyna, Joachimiak, Andrzej, Koide, Shohei, Rosner, Marsha Rich
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology (ASM) 2009
Sujets:
Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2643833/
https://ncbi.nlm.nih.gov/pubmed/19103740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01271-08
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires