Characterization of the Raf Kinase Inhibitory Protein (RKIP) Binding Pocket: NMR-Based Screening Identifies Small-Molecule Ligands

BACKGROUND: Raf kinase inhibitory protein (RKIP), also known as phoshaptidylethanolamine binding protein (PEBP), has been shown to inhibit Raf and thereby negatively regulate growth factor signaling by the Raf/MAP kinase pathway. RKIP has also been shown to suppress metastasis. We have previously de...

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Bibliographic Details
Main Authors: Shemon, Anne N., Heil, Gary L., Granovsky, Alexey E., Clark, Mathew M., McElheny, Dan, Chimon, Alexander, Rosner, Marsha R., Koide, Shohei
Format: Artigo
Language:Inglês
Published: Public Library of Science 2010
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2864760/
https://ncbi.nlm.nih.gov/pubmed/20463977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010479
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