In Vivo Fitness Cost of the M184V Mutation in Multidrug-Resistant Human Immunodeficiency Virus Type 1 in the Absence of Lamivudine

Lamivudine therapy selects for the M184V mutation. Although this mutation reduces the replicative capacity of human immunodeficiency virus in vitro, its impact on viral fitness in vivo has not been well defined. We used quantitative allele-specific PCR to precisely calculate the fitness differences...

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Bibliographic Details
Main Authors: Paredes, Roger, Sagar, Manish, Marconi, Vincent C., Hoh, Rebecca, Martin, Jeffrey N., Parkin, Neil T., Petropoulos, Christos J., Deeks, Steven G., Kuritzkes, Daniel R.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2009
Subjects:
Vaccines and Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2643770/
https://ncbi.nlm.nih.gov/pubmed/19019971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02154-08
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