In Vivo Fitness Cost of the M184V Mutation in Multidrug-Resistant Human Immunodeficiency Virus Type 1 in the Absence of Lamivudine

Lamivudine therapy selects for the M184V mutation. Although this mutation reduces the replicative capacity of human immunodeficiency virus in vitro, its impact on viral fitness in vivo has not been well defined. We used quantitative allele-specific PCR to precisely calculate the fitness differences...

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Detalhes bibliográficos
Main Authors: Paredes, Roger, Sagar, Manish, Marconi, Vincent C., Hoh, Rebecca, Martin, Jeffrey N., Parkin, Neil T., Petropoulos, Christos J., Deeks, Steven G., Kuritzkes, Daniel R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2643770/
https://ncbi.nlm.nih.gov/pubmed/19019971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02154-08
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