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Template Usage Is Responsible for the Preferential Acquisition of the K65R Reverse Transcriptase Mutation in Subtype C Variants of Human Immunodeficiency Virus Type 1

We propose that a nucleotide template-based mechanism facilitates the acquisition of the K65R mutation in subtype C human immunodeficiency virus type 1 (HIV-1). Different patterns of DNA synthesis were observed using DNA templates from viruses of subtype B or C origin. When subtype C reverse transcr...

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Autors principals: Coutsinos, Dimitrios, Invernizzi, Cédric F., Xu, Hongtao, Moisi, Daniela, Oliveira, Maureen, Brenner, Bluma G., Wainberg, Mark A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2643749/
https://ncbi.nlm.nih.gov/pubmed/19073730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01349-08
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