A Template-Dependent Dislocation Mechanism Potentiates K65R Reverse Transcriptase Mutation Development in Subtype C Variants of HIV-1

Numerous studies have suggested that the K65R reverse transcriptase (RT) mutation develops more readily in subtype C than subtype B HIV-1. We recently showed that this discrepancy lies partly in the subtype C template coding sequence that predisposes RT to pause at the site of K65R mutagenesis. Howe...

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Hauptverfasser: Coutsinos, Dimitrios, Invernizzi, Cédric F., Moisi, Daniela, Oliveira, Maureen, Martinez-Cajas, Jorge L., Brenner, Bluma G., Wainberg, Mark A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2011
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3105016/
https://ncbi.nlm.nih.gov/pubmed/21655292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0020208
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