Effects of the K65R and K65R/M184V reverse transcriptase mutations in subtype C HIV on enzyme function and drug resistance

BACKGROUND: We investigated the effects of mutations K65R and K65R plus M184V on enzymatic function and mechanisms of drug resistance in subtype C reverse transcriptase (RT). METHODS: Recombinant subtype C HIV-1 RTs containing K65R or K65R+M184V were purified from Escherichia coli. Enzyme activities...

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Detalhes bibliográficos
Main Authors: Xu, Hong-Tao, Martinez-Cajas, Jorge L, Ntemgwa, Michel L, Coutsinos, Dimitrios, Frankel, Fernando A, Brenner, Bluma G, Wainberg, Mark A
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2644664/
https://ncbi.nlm.nih.gov/pubmed/19210791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-6-14
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