Regulation of APOBEC3 Proteins by a Novel YXXL Motif in Human Immunodeficiency Virus Type 1 Vif and Simian Immunodeficiency Virus SIVagm Vif

The APOBEC3 cytidine deaminases are potent antiviral factors that restrict the replication of human immunodeficiency virus type 1 (HIV-1). In HIV-1-infected CD4(+) T cells, the viral accessory protein Vif binds to APOBEC3G (A3G), APOBEC3F (A3F), and APOBEC3C (A3C) and targets these proteins for poly...

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Bibliographic Details
Main Authors: Pery, Erez, Rajendran, Kottampatty S., Brazier, Andrew Jay, Gabuzda, Dana
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2009
Subjects:
Virus-Cell Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2643725/
https://ncbi.nlm.nih.gov/pubmed/19109396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01898-08
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