Meningococcal Outer Membrane Vesicle Vaccines Derived from Mutant Strains Engineered To Express Factor H Binding Proteins from Antigenic Variant Groups 1 and 2

Meningococcal outer membrane vesicle (OMV) vaccines, which are treated with detergents to decrease endotoxin activity, are safe and effective in humans. However, the vaccines elicit serum bactericidal antibody responses largely directed against PorA, which is antigenically variable. We previously pr...

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Bibliographic Details
Main Authors: Koeberling, Oliver, Giuntini, Serena, Seubert, Anja, Granoff, Dan M.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2009
Subjects:
Vaccine Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2643535/
https://ncbi.nlm.nih.gov/pubmed/19109451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00403-08
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