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Protective Antibody Responses Elicited by a Meningococcal Outer Membrane Vesicle Vaccine with Overexpressed Genome-Derived Neisserial Antigen 1870

BACKGROUND: Meningococcal outer membrane vesicle (OMV) vaccines are efficacious in humans but have serosubtype-specific serum bactericidal antibody responses directed at the porin protein PorA and the potential for immune selection of PorA-escape mutants. METHODS: We prepared an OMV vaccine from a N...

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Autors principals: Hou, Victor C., Koeberling, Oliver, Welsch, Jo Anne, Granoff, Dan M.
Format: Artigo
Idioma:Inglês
Publicat: 2005
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2373260/
https://ncbi.nlm.nih.gov/pubmed/16028126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1086/432102
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