Ablation of Ventricular Myosin Regulatory Light Chain Phosphorylation in Mice Causes Cardiac Dysfunction in Situ and Affects Neighboring Myofilament Protein Phosphorylation

There is little direct evidence on the role of myosin regulatory light chain phosphorylation in ejecting hearts. In studies reported here we determined the effects of regulatory light chain (RLC) phosphorylation on in situ cardiac systolic mechanics and in vitro myofibrillar mechanics. We compared d...

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Hauptverfasser: Scruggs, Sarah B., Hinken, Aaron C., Thawornkaiwong, Ariyaporn, Robbins, Jeffrey, Walker, Lori A., de Tombe, Pieter P., Geenen, David L., Buttrick, Peter M., Solaro, R. John
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2009
Schlagworte:
Protein Synthesis, Post-Translational Modification, and Degradation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2643522/
https://ncbi.nlm.nih.gov/pubmed/19106098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M807414200
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