Ablation of Ventricular Myosin Regulatory Light Chain Phosphorylation in Mice Causes Cardiac Dysfunction in Situ and Affects Neighboring Myofilament Protein Phosphorylation

There is little direct evidence on the role of myosin regulatory light chain phosphorylation in ejecting hearts. In studies reported here we determined the effects of regulatory light chain (RLC) phosphorylation on in situ cardiac systolic mechanics and in vitro myofibrillar mechanics. We compared d...

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Main Authors: Scruggs, Sarah B., Hinken, Aaron C., Thawornkaiwong, Ariyaporn, Robbins, Jeffrey, Walker, Lori A., de Tombe, Pieter P., Geenen, David L., Buttrick, Peter M., Solaro, R. John
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Protein Synthesis, Post-Translational Modification, and Degradation
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2643522/
https://ncbi.nlm.nih.gov/pubmed/19106098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M807414200
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