p53 Oligomerization Is Essential for Its C-terminal Lysine Acetylation

Acetylation of multiple lysine residues in the p53 plays critical roles in the protein stability and transcriptional activity of p53. To better understand how p53 acetylation is regulated, we generated a number of p53 mutants and examined acetylation of each mutant in transfected cells. We found tha...

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Bibliographic Details
Main Authors: Itahana, Yoko, Ke, Hengming, Zhang, Yanping
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Protein Synthesis, Post-Translational Modification, and Degradation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2643511/
https://ncbi.nlm.nih.gov/pubmed/19106109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M805696200
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